Mechanism of Action. resulting from hydroxylation of Xanthine derivatives (uric acid derivatives) or demethylation products showed to be able to repair radicals resulting from adenine oxidation [12]. Clinical significance. A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Xanthine DerivativesXanthine derivatives such as theophylline inhibit phosphodiesterase, resulting in an increase in cAMP. Ipratropium Bromide administration. The increase in cAMP causes relaxation of bronchial smooth muscle. These are plant alkaloids and components of coffee, tea and chocolate. Classification: Bronchodilator, Xanthine. Bronchial dilation and increase focus of contraction of diaphragmatic muscle. 5.14 Xanthine Derivatives Open Resources for Nursing (Open RN) Theophylline is a xanthine derivative. The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma or influenza symptoms. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine … C5-H4-N4-O2. Anti-inflammatory. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. Chemical Formula. Xanthine CAS registry number (Chemical Abstracts Service) 0000069-89-6. Anticholingeric Agent. Classifications of bronchodilators include beta 2-agonists, anticholinergics, and xanthine derivatives. In the case of antipyrine derivatives demethylation reactions from the amino group induced by the hydroxyl radical were also … The major pharmacologic actions of the xanthines are inhibition of tissue phosphodiesterases which i … In contrast to other, more potent stimulants like sympathomimetic amines, xanthines … Molecular Weight. These medications open the airways, but they work on different receptors in the body. Xanthine derivative Pregnancy Category C Therapeutic actions. ... Ipratropium Bromide classification. Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion. Xanthine derivatives Accession Number DBCAT001034 (DBCAT000503, DBCAT001028, DBCAT001220, DBCAT002203, DBCAT002692, DBCAT003295) Description. Therapeutic Categories. Indications This job aid also provides an overview of the approved security classification documents that assist in analyzing and evaluating … Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Two xanthine derivatives with high affinity and high selectivity for adenosine A 1 receptor, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (Lohse et al., 1987) and its analog 8-dicyclopropylmethyl-1,3-dipropylxanthine (KF15372) (Shimada et al., 1991), were selected as lead compounds for in vivo imaging. Xanthine Derivatives. Inhalation and Intranasal spray. 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