Ivy leaves (hederae helicis folium) exert an expectorant and antispasmodic action on the respiratory tract [1]. In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. Early research shows that taking a cough syrup containing English ivy leaf might improve coughing and breathing in children and adults with different types of bronchitis. ), Clear, Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 - Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children 5 Fl Oz (Pack of 1), Prospan 100mL By Helixia - Ivy Leaf Extract - Relieves Cough, Loosens Mucus & Phlegm, Zarbee's Naturals Baby Cough Syrup + Mucus with Agave & Ivy Leaf, Natural Cherry Flavor, 2 Ounce Bottle, Zarbee's Naturals Children's Cough Syrup* + Mucus Daytime & Nighttime, Grape Flavor, 4 Ounces (Pack of 2), Nature's Way B&T Nighttime Cough & Bronchial Syrup for Restful Sleep Homeopathic, Purple, Cherry 8 Fl Oz, Zarbee's Naturals Children's Cough Syrup* + Mucus with Dark Honey & Ivy Leaf, Cherry Flavor, 4 Ounce Bottle, Helixia Prospan Children's Cough Syrup ages 1 to 11, Children's Robitussin Naturals & Ivy Leaf Cough Relief Gummies, Dietary Supplement, Ages 3+, Honey, 30 Count, Robitussin Naturals Cough Relief Ivy Leaf Gummies 30ct, Robitussin Honey Adult Cough + Chest Congestion DM Maximum Strength Liquid & Robitussin Honey Adult Nighttime Cough DM Maximum Strength Liquid Value Pack (2-4 fl. CZ and EK are the employees of Max Zeller Söhne AG. 4.1 out of 5 stars 65. In principle, antitussives for the treatment of cough as a symptom of an acute bronchitis should have a good tolerability and low toxicity, especially when intended to be used in children. * More Buying Choices. The current noninterventional study was performed in 118 patients using EA 575® and 21 patients using ACC for the treatment of acute bronchitis. The research protocol was reviewed and approved by the Independent Ethics Committee, EKOS (Ethikkommission Ostschweiz) on 16.12.2016 (BASEC Nr. Objective. Liver disorders. The following symptoms were assessed by the patients or parents (interview by physician): Reduction of coughing intensity, chest pain during coughing, coughing related sleep disturbances, and possibility to cough-up mucus were comparable between both groups. Since data were incomplete for this patient, it was not considered in the overall study assessment. 2016-01555). The level of significance was α = 0.05. Recommended dosage according to the Swiss patient leaflet: for children six years and older, 5 ml, three times daily, and for adults, 7.5 ml, three times daily. Further, the patients were asked to keep a diary during the course of treatment, which includes following symptoms: number of coughing fits during daytime, coughing intensity, chest pain during coughing, dyspnoea during coughing, possibility to cough-up mucus, cough-related sleep disturbances, frequency of wake ups at night, and general well-being. L. Ivy leaf preparations are obtained as dry, liquid and soft extracts by putting the plant material in a solvent (such as ethanol) to dissolve compounds and form a liquid extract. In some studies, patients were requested to fill out diaries with daily assessments of, e.g., cough frequency, expectoration, and breathlessness. Average values of physician’s evaluation comparing the final visit with the entry visit. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The clinical effects of Hedera helix have been investigated in a total of more than 20 [12–14] clinical studies mostly in children suffering from upper airway infections. In most cases, only symptomatic treatment is needed [19, 20]. All symptoms showed a comparable improvement in the reduction of both groups from baseline to end visit. Introduction: Ivy leaf extract is an essential oil extracted from plant leaves. The German College of General Practitioners and Family Physicians (DEGAM) guidance describes the health-economic relevance of acute bronchitis as well [11]. It is characterized by a persistent cough which can be productive or dry. You’re seeing this ad based on the product’s relevance to your search query. The average age was 44.3 years for the EA 575® group and 49.1 years for the ACC group. Coferb contains Ivy Leaf extract that relieves cough and congestion. Esther Kruttschnitt, Tankred Wegener, Catherine Zahner, Silke Henzen-Bücking, "Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis", Evidence-Based Complementary and Alternative Medicine, vol. Diseases with the leading symptom “cough” are economically relevant as respiratory diseases are the most common reason for working incapacity and affect the quality of patient’s life [2]. Ivy Leaf Extract. Viral infection-caused acute bronchitis was the most common disease at entry visit with 53.4% in the EA 575® group and 57.1% in the ACC group, followed by other acute inflammation of the respiratory diseases with 25.4% in the EA 575® group and 33.3% in the ACC group. For both treatments, the change from the baseline bronchitis severity score (BSS) to the score at day 7 was calculated. Totally, 25 physicians were recruited in Switzerland who participated with 139 patients. Ivy is solid at its base, and then it starts to crawl. Prospan Chesty Cough Relief - Prospan Australia - Prospan … Active ingredient: Each 5 ml of syrup contains 35 mg of extract (as dry extract) from ivy leaf (Hedera helix L.) (5 - 7.5 : 1). Demographic parameters were compared between the study groups by chi-squared test or analysis of variance, as appropriate. The physician selected the patients for whom the diagnosis enabled them to be included into the study and to be treated with the abovementioned prescriptions. Results of trials with different extracts are only valid for the tested preparation but not for the tested plant [15]. Prospan syrup Ivy leaf dry extract Read all of this leaflet carefully before you start using this medicine because it contains important information for you. However, you still need to take ACTIVOX Ivy syrup carefully to get the best results from it. Other characteristic symptoms include sputum production, shortness of breath, and wheezing related to the obstruction of the inflamed airways. Sieben et al. It possesses antitussive and expectorant action that provides relief from bronchial cough and other associated respiratory afflictions. For dyspnoea during coughing, better improvement was seen in the EA 575® group. Ivy leaf dry extract HRS European Pharmacopoeia (EP) Reference Standard; find null-Y0001592 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Coferb Cough Syrup. Subgroup evaluation was performed within the EA 575® group regarding indication at inclusion into the study and concomitant disease or infection. EA 575® is effectively independent of the indication or concomitant disease. $16.39$16.39 ($3.21/Fl Oz) FREE Shipping. [12] in children and adults. This advantage could be demonstrated by the improvement of coughing fits, sputum, rales, dyspnoea, and severity of the disease during the 7 day-treatment as the primary outcome which was expressed by the BSS. The first patient was recruited in January 2017, and the last visit of the last patient was in March 2018. * Then, we add Turmeric Root for nasal support and Vitamin C and Zinc for immune support. At the final visit after seven days of treatment, there was a comparable improvement in both groups for all assessments except dyspnoea and number of cough attacks which showed a higher improvement in the EA 575® group compared with ACC. This medicine is available without prescription. Acute bronchitis is usually a self-limited condition. Concomitant diseases were mainly treated with antibiotics and other treatment (Table 4). English ivy exhibits antiviral, antimycotic, and anthelmintic and effects and some studies indicate that the This covered the indication of acute bronchitis and included the typical symptoms such as cough, sputum (phlegm) production, shortness of breath, and wheezing related to the obstruction of inflamed airways. Bottles), Garden of Life Elderberry Zinc Support for Adults Kids 12 and Older, mykind Organics Cough & Mucus Syrup with Ivy Leaf, Vitamin C Echinacea, No Added Sugars, 6.59 Fl Oz, Garden of Life Elderberry Zinc Immune Support for Kids, mykind Organics Kids Cough & Mucus Immune Syrup with Ivy Leaf, Vitamin C and Echinacea for Children, Alcohol Free, No Added Sugars, 3.92 fl oz, Terry Naturally Bronchial Clear Liquid - 3.4 fl oz - Soothing Lung & Upper Respiratory Function Support Supplement, Non-Drowsy, Non-Jittery - Gluten-Free - 20 Servings, Zarbee's Naturals Children's Cough Syrup* with Dark Honey Daytime & Nighttime, Grape, 4 Ounces (Pack of 2), Banyan Botanicals Bronchial Support – Organic Herbal Syrup for Children & Adults – Soothing & Comforting, Supports a Healthy Respiratory System* – 6oz. Out of the 139 data sets, 30 children were analysed with an average height of 136.0 cm and an average weight of 32.3 kg. Each patient had the right to terminate the study participation at any time. One patient reported at the final visit to have “discontinued treatment” after 8 days and switched to ACC due to lack of efficacy. Your recently viewed items and featured recommendations, Select the department you want to search in, All customers get FREE Shipping on orders over $25 shipped by Amazon, Try our simple and soothing honey cough syrup, Zarbee's Naturals Cough Syrup + Mucus Nighttime with Melatonin, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals Cough Syrup* + Mucus, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals 96% Honey Cough Soothers + Mucus with Ivy Leaf Extract, Lemon Menthol Flavor, 14 Count. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. Further, cough-associated sleeping disorders improved more in the EA 575® group. * Ivy leaf supports healthy mucosa beginning with the nose, mouth, and throat, and continuing to the bronchial passageways and lungs. Syrup: for children up to 12 years, 5 ml, three times daily, and for 12 years and older and adults, 10 ml, three times daily. I was prescribed ivy leaf extract for my (quite heavy) cough. Prime members enjoy FREE Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. Comparable improvement was seen for all symptoms between both groups from the entry to final visit which was statistically significant. In the current study design (noninterventional study), the physicians were totally free in their prescription decision. Ivy leaf Extract Syrup. Description: Cofif syrup contains IVY Leaf extract. Ivy leaf extract is a traditional ingredient that has been used for centuries to support bronchial health. No statistical significance was seen between the treatments. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bro… The physician was totally free in his or her decisions of therapy. 13 children belonged to the class group 6–11 years with an average height of 136.0 cm and an average weight of 32.3 kg. Coughing fits was the most common finding. The study revealed a significant and clinically relevant improvement in patients with acute bronchitis receiving oral treatment with EA 575®. Relevant concomitant diseases and treatments. There was a significant improvement in the reduction of both groups from baseline to end visit. In the United States, acute bronchitis is the ninth most common illness among outpatients, as reported by physicians [9]. The severity of the disease started with 4.3 points in the EA 575® group and with 4.24 points in the ACC group showing a moderate status of disease. Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. Fortified with Lactobacillus Paracasei MCC1849, a patented probiotic from Japan. The data used to support the findings of this study are available from the corresponding author upon request. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. Essentially, all captured data are calculated as frequency distributions and descriptive analysis (e.g., averages, medians, standard deviations, minimums, and maximums). These positive results for the herbal medication correspond to the pharmacological actions of ivy. Product: Cofif Plus Syrup. Maty's Organic Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. Two-hundred and sixty-eight children aged 0-12 yr were … Probably the drug-related AEs (adverse drug reactions (ADRs)) were in accordance with the known side-effect profile of ivy preparations. Both, physicians and patients described the efficacy of EA 575® comparable with acetylcysteine. Cough and fever are the most common symptoms of acute bronchitis in children. 7 children were noted in the class group 11–13 years with an average height of 137.1 cm and an average weight of 37.0 kg. Nat Med 1999;14:28–33. The main components of ivy leaf that give it its health benefits are called saponins. The daily self-assessment of patient’s documentation for days 1–6 was done with 5-stage-scored questions except for number of coughing fits and frequency of wake ups at night which have a 4-stage-score. One patient reported diarrhea after she had used EA 575® for two days, and after discontinuing of the medication, the patient had recovered. In summary, the study showed that both preparations are effective and safe in the treatment of bronchitis. Drop-outs were only those patients, for which no data after intake of the medication were available. dried ivy leaf extract 【Botanic Name】Hedera helix L. 【Use Part】Leaf 【Specifications】10%-40% Hederacosides, 3%-20% Hederacoside C, 10:1. Product: Cofif Syrup. The evaluation of the individual data on symptoms was only carried out for those patients in whom the symptom was present at the beginning of the study. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. All tests were performed using IBM SPSS for Windows software, version 25. The authors declare that there are no conflicts of interest. Zarbee's Naturals Cough & Throat Relief + Mucus Nighttime Drink Mix, Apple Spice Flavor, 6 Packets, FREE Shipping on orders over $25 shipped by Amazon, Zarbee's Naturals 99% Honey Cough Soothers, Natural Lemon Flavor, 14 Count, Zarbee's Naturals Baby Cough Syrup* + Mucus, Natural Grape Flavor, 2 Ounces, Integrative Therapeutics - Sambucus - Black Elderberry Syrup - Support Immune System & Cold and Flu Relief Supplement - Berry Flavor - 4 fl oz, Nature's Way Bronchial Soothe Ivy Leaf 99.9% Alcohol-free Non-Drowsy Syrup, 120 ML (4 Fl Oz. The stimulation of β2-AR provides an increased surfactant production which leads to the liquefaction of the mucus. Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist told you. Our cough syrup works as a bronchodilator and an expectorant which eases chest congestion, inflammation of the trachea and soothes sore throat. The average of findings for coughing fits, sputum, dyspnoea, and rales assessed by the physicians is shown in Figure 1. During the final visit, after approximately 1 week, information on the therapy and the course of the symptoms was documented. Husten und Auswurf: ursachen und Differentialdiagnosen,”, J. E. DeLozier and R. O. Gagnon, “National ambulatory medical care survey: 1989 summary,”, K. F. Chung and I. D. Pavord, “Prevalence, pathogenesis, and causes of chronic cough,”, C. C. S. Lang and T. Wegener, “Efeu in der pädiatrischen Praxis,”, A. Schaefer, F. Ludwig, B. M. Giannetti, M. Bulitta, and A. Wacker, “Efficacy of two dosing schemes of a liquid containing ivy leaves dry extract EA 575 versus placebo in the treatment of acute bronchitis in adults,”, A. Schaefer, M. S. Kehr, B. M. Giannetti, M. Bulitta, and C. Staiger, “A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575((R))) vs. placebo in the treatment of adults with acute cough,”, P. Kardos, Q. Dinh, K.-H. Fuchs et al., “Leitlinie der deutschen gesellschaft für pneumologie und beatmungsmedizin zur diagnostik und therapie von erwachsenen patienten mit husten,”, P. Kardos, S. Lehrl, W. Kamin, and H. Matthys, “Assessment of the effect of pharmacotherapy in common cold/acute bronchitis - the bronchitis severity scale (BSS),”, B. Kemmerich, R. Eberhardt, and H. Stammer, “Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough,”, F. J. Martinez, “Acute bronchitis: state of the art diagnosis and therapy,”, A. Gillissen, C. Gessner, S. Hammerschmidt, G. Hoheisel, and H. Wirtz, “Acute bronchitis: when are antibiotics, and when is symptomatic treatment indicated?”, G. Höffken, J. Lorenz, W. Kern et al., “S3-guideline on ambulant acquired pneumonia and deep airway infections,”, N. A. Sathe, S. Krishnaswami, J. Andrews, C. Ficzere, and M. L. McPheeters, “Pharmacologic agents that promote airway clearance in hospitalized subjects: a systematic review,”, Y. Bolbot, E. Prokhorov, S. Mokia, and A. Yurtseva, “Comparing the efficacy and safety of high-concentrate (5-7.5:1) ivy leaves extract and acetylcysteine for treatment of children with acute bronchitis,”, A. Sieben, L. Prenner, T. Sorkalla et al., “Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors,”. The validated method was successfully applied to quantify all six compounds in a 30% ethanol ivy leaf extract and 13 ivy leaf extract products. It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk-benefit ratio. oz. Subsequently, treatments were prescribed by the doctor. In Europe, the prevalence for cough is 33% in the population group aged 18 to 48 years [10]. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. described the mode of action stating that α-hederin inhibited the terbutaline-stimulated internalization of the β2-AR. The following clinical findings were documented during both visits by the physicians in accordance with the Bronchitis Severity Score (BSS) [16] by a 5-stage assessment: coughing fits, sputum, rales/rhonchi, and dyspnoea during coughing. With the exception of height, each of the demographic parameters was not significantly different between the study groups (Table 1). Patients themselves rated the following symptoms that were queried by the physician: 5-staged-score for coughing intensity, chest pain during coughing, dyspnoea during coughing, cough-related sleep disturbances, and possibility to cough-up mucus and 4-staged-score for number of coughing fits during daytime. Of the 118 patients included in the evaluation with EA 575®, treatment was carried out over an average period of 7.48 days. Ivy Leaf Cough Syrup Benefits: Natural formula to reduce coughing, soothe airways and to clear mucus and phlegm or effective congestion and cough relief. Acute bronchitis is a clinical term implying a self-limited inflammation of the large airways of the lung that is characterized by cough without pneumonia. Complement Med Res 2005;12(6):328-32. ACC mono acetylcysteine preparation (granulate, syrup, or effervescent tablet, products available in the Swiss market): The following doses are recommended according to the summary of product characteristics. It relieves cough naturally and makes breathing easy. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. ( You can buy English Ivy plant here: English Ivy 4 Plants -- Hardy Groundcover -- Great Bonsai ). The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575® by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. A previous multicenter study showed that EA 575® exerts mucolytic action equal to acetylcysteine but with better tolerability [23]. Material and Methods. Extraction solvent: ethanol 30 % w/w. At the inclusion visit, demographic and anamnestic data as well as the indication and typical complaints were recorded in the case report form. The exclusive ivy extract in Bronchial Soothe provides herbal support for optimal lung and bronchial passageway health. These components are supportive of healthy mucous membranes and defend against occasional irritation of the lung and bronchial passages. The present Swiss study investigated the intake of EA 575® and acetylcysteine and confirmed the results from Lang et al. Before recruitment, the study procedure was explained to the subjects in detail, after which they signed consent forms. Average weight was 66.1 kg in the EA 575® group and 71.7 kg in the ACC group. Hedera helix preparations (ivy leaf extracts) are worldwide marketed for the treatment of different diseases of the respiratory tract system and include catarrh of the respiratory passages; symptomatic treatment of chronic inflammatory bronchial illnesses; and acute inflammations of the respiratory tract accompanied by coughing (HMPC Assessment) [1]. Another noninterventional study investigated the efficacy and safety of EA 575® in school children with acute bronchitis showing the same improvement in the BSS [12]. Alternative & Herbal Products. We are committed to sharing findings related to COVID-19 as quickly as possible. You may need to read it … In addition, the EA 575® preparation showed to be effective in children and adults independent of the indication or concomitant disease and can therefore be used as an alternative to the synthetic ACC preparation. The data of all patients were analysed on an intend-to-treat basis, which had used at least one dose of the medication. 2020, Article ID 1910656, 7 pages, 2020. https://doi.org/10.1155/2020/1910656, 1Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, 2CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, 3Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland. 47 male and 71 female subjects were included into the EA 575® group, and 11 male and 10 female subjects were included into the ACC group. The value of antibiotics or other synthetic products in the treatment of otherwise healthy subjects with acute bronchitis has not been established. Effect or tolerability data was compared by repeated general linear model analysis using data from entry and final visits as intrasubject variables, treatment as between subject factor, and sex and child/adults as covariates. UNDA - Drosera Plex Cough Syrup - Homeopathic Remedy for Temoporary Relief of Cough - 6.1 fl. Results of this multicenter study proved the advantage of the treatment of ivy leaves in acute bronchitis that is evidently comparable with acetylcysteine. Most studies were conducted with preparations containing the ivy leaf dry extract EA575® as active ingredient [12]. We start with our proprietary Dark Honey Blend and add English Ivy Leaf extract and Marshmallow Root Extract to soothe irritated throats and help your child clear mucus when they are coughing. IVY leaf. NAC hydrolyzes the disulfide bonds of mucus proteins to decrease the mucus viscosity, thereby facilitating its clearance [22]. Open trials to assess aspects of safety and efficacy of a combined herbal cough syrup with Ivy and Thyme. 24.6% of the subjects from the EA 575® group suffered from acute bronchitis caused by bacterial infection and 19.0% in the ACC group (Table 2). More info about ivy leaf extract. Over the entire treatment period, there was a reduction to 1.8 points in the EA 575® group and to 2.1 points in the ACC groups corresponding to a low impairment in both groups and showing a comparable continuous improvement in both groups. Mild stomach problems.. not enough is known about the safety of applying English ivy the... Leaf dry extract bronchodilator and an average weight of 32.3 kg the exclusive ivy extract in bronchial Soothe et... Acc group cz and EK are the employees of Max Zeller Söhne AG, physicians and patients described the of... 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Provides herbal support for optimal lung and bronchial passages a natural cough syrup - Homeopathic for! Dosage forms demographic and anamnestic data as well ( Table 3 ) disulfide bonds of mucus to... 23 ] components are supportive of healthy mucous membranes and defend against irritation... Current study design ( noninterventional study the therapy and the physicians is shown in Figure.., Ramos M, Melzer J of trials with different extracts are valid! The skin with EA 575® group regarding indication at inclusion into the study was at. Completely evaporated to obtain a soft or dry extract most common illness among outpatients, as appropriate from baseline end! Is then partially or completely evaporated to obtain a soft or dry extract across dosage... For all symptoms showed a comparable improvement in the evaluation with EA 575® 21. * ivy leaf dry extract are committed to sharing findings related to class. 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Oz- Helps Maintain respiratory and ivy leaf extract syrup ivy leaf extract 【Botanic Name】Hedera helix 【Use...

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